What rare genetic variants are considered in the breast and ovarian cancer models?
CanRisk v2 introduced more pathogenic variants. The differences between CanRisk v1 and v2 are given below with the genes included in the model marked with and those not included marked with .
Rare genetic variants considered in the breast cancer model
Gene | CanRisk v1 (BOADICEA v5) | CanRisk v2 (BOADICEA v6) |
---|---|---|
BRCA1 | ||
BRCA2 | ||
PALB2 | ||
CHEK2 | ||
ATM | ||
RAD51C |
| |
RAD51D |
| |
BARD1 |
| |
BRIP1 |
|
|
Rare genetic variants considered in the ovarian cancer model
Gene | CanRisk v1 | CanRisk v2 |
---|---|---|
BRCA1 | ||
BRCA2 | ||
PALB2 |
| |
CHEK2 |
|
|
ATM |
|
|
RAD51C | ||
RAD51D | ||
BARD1 |
|
|
BRIP1 |