What rare genetic variants are considered in the breast and ovarian cancer models?

CanRisk v2 introduced more pathogenic variants. The differences between CanRisk v1 and v2 are given below with the genes included in the model marked with and those not included marked with .

Rare genetic variants considered in the breast cancer model

Gene

CanRisk v1 (BOADICEA v5)

CanRisk v2 (BOADICEA v6)

Gene

CanRisk v1 (BOADICEA v5)

CanRisk v2 (BOADICEA v6)

BRCA1

BRCA2

PALB2

CHEK2

ATM

RAD51C

RAD51D

BARD1

BRIP1

Rare genetic variants considered in the ovarian cancer model

Gene

CanRisk v1

CanRisk v2

Gene

CanRisk v1

CanRisk v2

BRCA1

BRCA2

PALB2

CHEK2

ATM

RAD51C

RAD51D

BARD1

BRIP1