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Sex
Age or age at death
Year of birth
Age at first breast cancer diagnosis if applicable
In general, if you add unaffected family members (who have not developed cancer) to a pedigree, this will tend to lower the mutation carrier probabilities and breast/ovarian cancer risks predicted by the CanRisk Tool (other things being equal).
If your pedigree has a weak family history of cancer and includes many unaffected family members (relatives of the index), these unaffected family members will be taken into account when the index’s breast/ovarian cancer risks are computed. However, these unaffected family members will not be taken into account when the program computes the equivalent baseline breast/ovarian cancer risks. Under these circumstances, the index’s breast/ovarian cancer risks can be lower than the equivalent baseline breast/ovarian cancer risks.