The following information is used to determine risks:
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Table of Risk Factors
Risk Factor | Breast Cancer | Ovarian Cancer |
|---|---|---|
Family and personal-proband history of breast, ovarian, prostate and pancreatic cancer |
|
|
Rare pathogenic variants in moderate and high risk susceptibility genes |
...
|
...
, |
|
...
Age information on unaffected family members |
|
|
Ashkenazi Jewish origin |
|
|
Information on year of birth to capture birth cohort |
...
The following risk factors are used:
|
|
Age |
...
of |
...
menarche |
| |
Parity |
|
|
Age |
...
at |
...
first |
...
live |
...
birth |
| |
Use |
...
of |
...
oral |
...
contraception |
|
|
Use |
...
of |
...
menopause |
...
hormone |
...
therapy |
|
|
Body |
...
mass |
...
index |
|
|
Daily |
...
alcohol |
...
intake |
| |
Mammographic |
...
density |
| |
Height |
|
|
Tubal |
...
ligation |
...
procedure |
| |
Endometriosis |
| |
Common |
...
cancer |
...
genetic |
...
susceptibility |
...
variants |
...
Risk |
...
Scores) |
|
|
- indicates used by cancer risk prediction model
The cancer models allow for missing information on the various genetic, other risk factors, or pedigree data (i.e. it is not essential not have all information available), but users should aim to enter complete information where possible.
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