What information do the breast and ovarian cancer models use to determine risks?

Table of Risk Factors 

Risk Factor

Breast Cancer

Ovarian Cancer

Risk Factor

Breast Cancer

Ovarian Cancer

Family and personal-proband history of breast, ovarian, prostate and pancreatic cancer

Rare pathogenic variants in moderate and high risk susceptibility genes


BRCA1, BRCA2, PALB2, CHEK2, ATM,
RAD51D, RAD51C,
BARD1


BRCA1, BRCA2,
PALB2, RAD51D, RAD51C, BRIP1

Age information on unaffected family members

Ashkenazi Jewish origin

Information on year of birth to capture birth cohort

Age of menarche



Parity

Age at first live birth



Use of oral contraception

Use of menopause hormone therapy

Body mass index

Daily alcohol intake



Mammographic density



Height

Tubal ligation procedure



Endometriosis



Common cancer genetic susceptibility variants
(Polygenic Risk Scores)























































 - indicates used by cancer risk prediction model

  

The cancer models allow for missing information on the various genetic, other risk factors, or pedigree  data  (i.e. it is not essential not have all information available), but users should aim to enter complete information where possible.