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The default

BRCA

genetic test sensitivities

were agreed after discussions with UK clinical genetics groups in 2019. These discussions

are described in Lee et al. 2022. These considered the technologies used at the time

and

of the model development

process,

and allowances were made for possible Variants of Unknown Significance (not called as pathogenic) contributing to disease.

Genetic test sensitivities may vary across labs. If your genetic testing laboratory uses tests that are highly sensitive (e.g. including screening for large re-arrangements) and you believe the testing sensitivity is higher, then you can adjust the BRCA genetic test sensitivities in the CanRisk Tool to take account of that in risk calculations (see: How can I change the genetic test sensitivity?).