Date: Fri, 29 Mar 2024 14:44:51 +0000 (UTC)
Message-ID: <662532792.15.1711723491124@3f643be788d5>
Subject: Exported From Confluence
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How were the default gene-specific genetic test sensitivities in=
the CanRisk Tool chosen?=C2=A0
How were the default gene-specific genetic test sensitivities in th=
e CanRisk Tool chosen?=C2=A0
The default genetic test sensitivities are described in Lee et al. 2022. These considered the technologies used at the time of the model developm=
ent and allowances were made for possible Variants of Unknown Significance =
(not called as pathogenic) contributing to disease.
Genetic test sensitivities may vary across labs. If your genetic tes=
ting laboratory uses tests that are highly sensitive (e.g. including screen=
ing for large re-arrangements) and you believe the testing sensitivity is h=
igher, then you can adjust the BRCA genetic test sensitivities in the CanRi=
sk Tool to take account of that in risk calculations (see: How can I change the genetic test sensitivity?).=
h3>
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