The following information is used to determine risks:
The family history of breast, ovarian, prostate and pancreatic cancer
Rare pathogenic variants in moderate and high risk susceptibility genes:
BRCA1, BRCA2, PALB2, CHEK2, ATM for breast cancer
BRCA1, BRCA2, RAD51D, RAD51C, BRIP1 for ovarian cancer
Age information on unaffected family members
Ashkenazi Jewish origin
Information on year of birth to capture birth cohort
- Additionally the
The following risk factors are used:
Risk Factor | Breast Cancer | Ovarian Cancer |
---|---|---|
Age of menarche | ||
Parity | ||
Age at first live birth | ||
Use of oral contraception | ||
Use of menopause hormone therapy | ||
Body mass index | ||
Daily alcohol intake | ||
Mammographic density | ||
Height | ||
Tubal ligation procedure | ||
Endometriosis | ||
Common cancer genetic susceptibility variants |