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The following information is used to determine risks:

The family

Table of Risk Factors 

Risk FactorBreast CancerOvarian Cancer

Family history of breast, ovarian, prostate and pancreatic cancer

(tick)(tick)

Rare pathogenic variants in moderate and high risk susceptibility genes

:

(tick)
BRCA1, BRCA2, PALB2, CHEK2, ATM

for breast cancer risk

(tick)
BRCA1, BRCA2, RAD51D, RAD51C, BRIP1
for ovarian cancer risk
Risk FactorBreast CancerOvarian Cancer

Age information on unaffected family members

(tick)(tick)

Ashkenazi Jewish origin

(tick)(tick)

Information on year of birth to capture birth cohort

  • The following risk factors are used:

    • (tick)(tick)

    Age

    of

    menarche

    		(tick)

    Parity

    		(tick)(tick)

    Age

    at

    first

    live

    birth

    		(tick)

    Use

    of

    oral

    contraception

    		(tick)(tick)

    Use

    of

    menopause

    hormone

    therapy

    		(tick)(tick)

    Body

    mass

    index

    		(tick)(tick)

    Daily

    alcohol

    intake

    		(tick)

    Mammographic

    density

    		(tick)

    Height

    		(tick)(tick)

    Tubal

    ligation

    procedure


    		(tick)

    Endometriosis


    		(tick)

    Common

    cancer

    genetic

    susceptibility

    variants
    (Polygenic

    Risk

    Scores)

    		(tick)(tick)




























    (tick) - indicates used by cancer risk prediction model

      

    The cancer models allow for missing information on the various genetic, other risk factors, or pedigree  data  (i.e. it is not essential not have all information available), but users should aim to enter complete information where possible.