The following information is used to determine risks:
The family history of breast, ovarian, prostate and pancreatic cancer
Rare pathogenic variants in moderate and high risk susceptibility genes:
BRCA1, BRCA2, PALB2, CHEK2, ATM for breast cancer risk
BRCA1, BRCA2, RAD51D, RAD51C, BRIP1 for ovarian cancer risk
Age information on unaffected family members
Ashkenazi Jewish origin
Information on year of birth to capture birth cohort
The following risk factors are used:
| Risk Factor | Breast Cancer | Ovarian Cancer |
|---|---|---|
Age of menarche |  | |
Parity | | |
Age at first live birth | | |
Use of oral contraception | | |
Use of menopause hormone therapy | | |
Body mass index | | |
Daily alcohol intake | | |
Mammographic density | | |
Height | | |
Tubal ligation procedure | | |
Endometriosis | | |
Common cancer genetic susceptibility variants | | |
The cancer models allow for missing information on the various genetic, other risk factors, or pedigree data (i.e. it is not essential not have all information available), but users should aim to enter complete information where possible.
