1. It is important to keep in mind that the predicted risk is determined only by the genetic and other risk factors considered in the model (see 3. Importantly, treatment
The BOADICEA model includes the following assumptions/limitations when it computes contralateral breast cancer risk:
1. Contralateral breast cancer risk is computed using only the following information for the index:
Age at diagnosis of the first breast cancer
Genetic and other risk factors
No other information is considered in predicting contralateral breast cancer risk.
See What information do the breast and ovarian cancer models use to determine risks?
). The model uses information on the age at diagnosis of the first breast cancer, assuming that only one breast remains at risk, to make predictions for contralateral breast cancer on the basis of the assumed geneticand
other risk factors (for details seeAntoniou et al. Br J Cancer 2008
)for additional information.
2. No other information is considered in predicting contralateral breast cancer risk.
2. The model assumes that only one breast remains at risk.
3. Treatment of the first cancer (in particular hormonal therapy etc) and tumour pathology are important risk factors for contralateral breast cancer
which. However, these risk factors are not taken into account by the model. For example, systemic treatment is associated with a reduction in contralateral breast cancer risk. This is a limitation of the model which we aim to address in
forthcoming model iterationsthe future.
