What information do the breast and ovarian cancer models use to determine risks?


Table of Risk Factors 

Risk FactorBreast CancerOvarian Cancer

Family and personal-proband history of breast, ovarian, prostate and pancreatic cancer

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Rare pathogenic variants in moderate and high risk susceptibility genes

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BRCA1, BRCA2, PALB2, CHEK2, ATM

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BRCA1, BRCA2, RAD51D, RAD51C, BRIP1

Age information on unaffected family members

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Ashkenazi Jewish origin

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Information on year of birth to capture birth cohort

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Age of menarche

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Parity

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Age at first live birth

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Use of oral contraception

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Use of menopause hormone therapy

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Body mass index

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Daily alcohol intake

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Mammographic density

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Height

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Tubal ligation procedure


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Endometriosis


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Common cancer genetic susceptibility variants
(Polygenic Risk Scores)

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(tick) - indicates used by cancer risk prediction model

  

The cancer models allow for missing information on the various genetic, other risk factors, or pedigree  data  (i.e. it is not essential not have all information available), but users should aim to enter complete information where possible.