Can the target/proband can be changed?

It is possible to change the proband. Before you switch it is recommended that you save the current pedigree data and risk factors (use the "Save" button at the top of the tool). In the “Family History” section you can select the new proband by clicking on them in the pedigree graphic. Ensure the new proband has been given an age and year of birth in the “Individual’s Details” panel. Then you can click “Proband". A warning dialog will popup to ensure you have saved the current risk factors and pedigree. If you select “Continue” the pedigree will be updated and you will need to complete the risk factor sections for the new proband.