The breast and ovarian cancer risk models used by the CanRisk Tool have been developed using data from European ancestry populationsprimarily using data for the UK, and are therefore most applicable to the British population. They should, however, work reasonably well in other Western populations.
Certain other populations have higher frequencies of BRCA1 and/or BRCA2 mutations. These include Iceland, Poland and the Netherlands. Modifications to the risk calculations may be required for these populations.
The CanRisk Tool has not been evaluated in populations at lower risk of breast cancer (such as far Eastern or developing countries). Predictions in these populations (particularly of the cancer risk) are likely to be unreliable.
