The program can be used to calculate risks for individuals with Ashkenazi Jewish ancestry. Below this is a description of how to do that in the CanRisk tool and for the web-services.
Instructions
In the CanRisk Tool:
Enter the “Family History” section in the tool.
In the prompt: Have you any Ashkenazi Jewish ancestors? Select the Ashkenazi Jewish.
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If 'CUSTOM' is used then the custom mutation frequencies can be defined for each gene (using the gene parameters 'brca1_mut_frequency', 'brca2_mut_frequency' etc). |
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