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At present, the risk models used by the CanRisk Tool (in particular the Polygenic Risk Scores) have only been validated for women of European ancestry. Therefore, the CanRisk Tool is most applicable to European populations.  It should, however, work reasonably well in other Western populations.

Certain other populations have higher frequencies of BRCA1 and/or BRCA2 mutations. These include Iceland, Poland and the Netherlands. Modifications to the risk calculations may be required for these populations.

The CanRisk Tool has not been evaluated in populations at lower risk of breast cancer (such as far Eastern or developing countries). Predictions in these populations (particularly of the cancer risk) are likely to be unreliable.