Description
CanRisk Pedigree Data v3 Files contain the target individual's risk factors (optional) in the header followed by pedigree data (mandatory) as a series of pedigree data records, one for each family member. The following sections describe the format of the File Header and the Pedigree Data records.
File Header
The File Header can optionally include the following breast and/or ovarian cancer risk factors for the target individual:
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† Breast Cancer Risk Factor ‡ Ovarian Cancer Risk Factor
The PRS_BC and PRS_OC values are:
- alpha - the square root of the proportion of the overall polygenic variance explained by the PRS. A real number between 0 and 1.
- zscore – the standard normal PRS.
UK based Ethnic Groups and Background
| Ethnic group | Ethnic background |
|---|---|
| White | English/Welsh/Scottish/Northern Irish/British |
| Mixed/Multiple ethnic groups | White and Black Caribbean |
| Asian or Asian British | Indian |
| Black or Black British | African |
| Other ethnic group | Arab |
| Unknown |
...
| Info | ||
|---|---|---|
| ||
##CanRisk 3.0 |
Pedigree Data
The CanRisk Pedigree Data Format is a simple TAB-delimited text format. CanRisk pedigree data files consist of the two mandatory header records followed by a series of pedigree data records, one for each family member. The pedigree data records include 27 parameters (data columns) separated by a single TAB (or whitespace) character.
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